New Manc-COJO tool in preprint

New software developed at SMARTbiomed has passed the SMARTbiomed internal review process. The manuscript describing the recently-developed tool for Multi-Ancestry Conditional and Joint Analysis (“Manc-COJO”) is currently under review for publication and is available as a preprint at biorxiv.com. You can find it and other software tools developed by SMARTbiomed researchers on our website’s “Software” page.

The tool, developed by SMARTbiomed research fellows Mark Xiaotong Wang and Yong Wang in collaboration with Loic Yengo and SMARTbiomed leaders Naomi Wray and Peter Visscher, is a promising innovation in its field. Author Mark Xiaotong Wang explains: “We extend a widely used software- COJO- for identifying and counting independent trait-associated genetic variants to scenarios where contributing data sets are drawn from multiple genetic ancestries. Notably, the software tool has improved on the computational approach in regular COJO, so that is around one hundred times faster than the original version. That improvement is not just a technical detail—it has a substantial practical impact. For large-scale genomic analyses, reducing computation time at that scale translates into significant savings in both time and resources, and makes certain analyses far more feasible than before.” Please look out for updates on our website when the paper is accepted for publication.